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To send mail using SMTP with Lotus Notes Domino, you first need to configure the Domino server to enable SMTP by setting up the SMTP task in the server's configuration. Next, create a mail database for users and ensure that the SMTP settings are correctly configured under the Mail settings in the Domino Administrator. Finally, you can use the Lotus Notes client or an application to send emails by specifying the recipient's email address and using the SMTP protocol to relay the message through the Domino server. Make sure that the relevant ports (typically port 25) are open for SMTP communication.

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