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There are a number of disasters that have happened on board spacecraft. Some of the best known ones are these:

The Apollo 1 cockpit fire during a pre-flight launchpad testing session. This killed three astronauts.

The Apollo 13 oxygen tank explosion en-route to the moon, which crippled the spacecraft and while the landing was aborted, all three astronauts returned safely to earth.

The more recent Challenger and Columbia space shuttle disasters have claimed the lives of seven astronauts each. On Challenger, a faulty seal on a solid rocket booster resulted in the puncture and explosion of the main fuel tank. On Columbia, a small hole in the underside of the wing protective tiles was made from foam falling from the fuel tank during launch. The extent of the problem was not realized, until after the shuttle was pulled apart during re-entry because of the effects of heat damaging the wing structure.

The link below details these and many more. The first page includes fatal disasters, the second page is about non-fatal disasters.

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