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The actual cause of his death is a mystery.

Medical science at that time was quite primitive.

Speculation includes, Alcoholism, cerebral inflammation, brain congestion, cholera, meningitis, rabies, epilepsy, syphilis, heart disease, and fever delirium

Another theory is "cooping." This is a practice where local thugs force people to vote several times so as to fraudulently get their candidates elected. Poe was found incoherent outside a saloon that had been used as a polling place in an election the day before. He was also found wearing clothes that were not his. Many times people dressed differently, cut off beards and mustaches to look different to poll workers in order to vote more than once. Some people were beaten or gotten drunk to persuade them to cooperate even if they did not want to.

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