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In 1921, at the direction of Dupont Corporation the maker of tetraethyl lead, Thomas Midgley Jr. found the compound to be an effective antiknock agent, while working under Charles Kettering of General Motors Corporation's Dayton Research Laboratories. Midgley nearly killed himself from lead poisoning after over a year of working with the compound and took a prolonged vacation in 1923 to Miami, Florida for convalescence.

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