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Yes you can. There are many beautiful places to visit along the way. Mexico's Gulf Coast is a completely different experience than Cancun. A driving trip will expose you to more of "real" Mexico than flying.

The direct route from Matamoros, TAM to Cancun QR, taking toll roads when available, is about 1635 miles. It CAN be done in 3 days, but I recommend a minimum of 5, because the driving is more demanding.

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