How far from Kansas City MO to Cape Girardeau MO?

Answer 1

355 miles taking this route:

1. Take I-70 EAST to I-55 SOUTH to Memphis via I-270 SOUTH around St. Louis. (Exit at EXIT 232B off I-70 to get onto I-270 SOUTH, then exit at EXIT 1A to get onto I-55 SOUTH towards MEMPHIS.)
2. Take I-55 SOUTH to Cape Girardeau.