How many drving miles from Louisville KY to Charleston sc?

Answer 1

614 miles taking this route:

1. Take I-64 EAST, from Louisville, to I-75 SOUTH to KNOXVILLE in Lexington.
2. Continue on I-75 SOUTH to I-40 EAST to ASHEVILLE, via I-640 EAST to bypass KNOXVILLE.
3. Take I-40 EAST to I-26 EAST to SPARTANBURG at EXIT 46A in Asheville.
4. Take I-26 EAST to Charleston.