Take I-79 SOUTH from Pittsburgh to U.S. 19 SOUTH to BECKLEY at EXIT 57 in WEST Virginia.
Take U.S. 19 SOUTH to I-77 SOUTH to BLUEFIELD in north Beckley; follow signs to I-77 SOUTH to BLUEFIELD.
Take I-77 SOUTH to I-74 EAST to MOUNT AIRY and WINSTON-SALEM at EXIT 101 in North Carolina.
Continue on I-74 EAST to U.S. 52 SOUTH towards Winston-Salem near Mount Airy.
Take U.S. 52 SOUTH to I-40 EAST to GREENSBORO at EXIT 107A in Winston-Salem.
Take I-40 EAST to I-73 SOUTH to ASHEBORO outside of Greensboro.
Take I-73 SOUTH to U.S. 220 SOUTH.
Continue on U.S. 220 SOUTH (FUTURE I-73/I-74) CORRIDOR to U.S. 1 SOUTH in Rockingham; continue straight onto U.S. 1 SOUTH, then take U.S. 1 SOUTH (briefly) to I-74/U.S. 74; follow signs to I-74/U.S. 74 EAST.
Take I-74/U.S. 74 EAST (briefly) to ROUTE 38 to HAMLET and BENNETTSVILLE at EXIT 319; turn right off the exit ramp onto ROUTE 38 EAST to BENNETTSVILLE.
Follow ROUTE 38 EAST to U.S. 501 SOUTH in South Carolina.