How many miles to drive from Tupelo MS to Lake Charles LA?

Answer 1

It is 484 miles according to Google Maps.

In Addition:

520 miles taking this route:

1. Take U.S. 278 WEST, from Tupelo, to I-55 SOUTH to GRANADA, near Batesville.
2. Take I-55 SOUTH down to I-12 WEST to Baton Rouge at EXIT 29B in Louisiana.
3. Take I-12 WEST to I-10 WEST to BATON ROUGE.
4. Take I-10 WEST to LAKE CHARLES.