I-85 South through Durham, Greensboro, and Charlotte.
The shortest route is I-75 N.
The shortest is I-80 East.
The driving distance from Myrtle Beach, SC to Oneonta, NY is approximately 850 miles. The exact distance can vary depending on the specific route taken.
I-55 S
Is it over 2,598 miles
The route with the shortest driving time is about 685 miles.
The route with the shortest driving time is about 430 miles.
The route with the shortest driving time is about 1,510 miles.
The route with the shortest driving time is about 19 miles.
The route with the shortest driving time is about 220 miles.
The route with the shortest driving time is about 115 miles.