What is the best driving route from Niagara Falls to Fort Myers FL?

Answer 1

1. Take I-190 SOUTH from Niagara falls to I-90 via I-290 (EXIT 16 off I-90). Once you are at I-90, follow signs to I-90 WEST to ERIE.
2. Take I-90 WEST to I-79 SOUTH to PITTSBURGH at EXIT 22B in ERIE, Pennsylvania.
3. Take I-79 SOUTH to U.S. 19 SOUTH to BECKLEY off EXIT 57 in WEST VIRGINIA.
4. Take U.S. 19 SOUTH to I-77 in north Beckley; at I-77, follow signs to I-77 SOUTH to BLUEFIELD.
5. Take I-77 SOUTH to I-26 EAST to CHARLESTON (TO I-95) at END I-77 in COLUMBIA, South Carolina.
6. Take I-26 EAST to I-95 SOUTH to SAVANNAH off EXIT 169A.
7. Take I-95 SOUTH to I-10 WEST via I-295 SOUTH to bypass JACKSONVILLE (EXIT 362B off I-95 in FLORIDA to get onto I-295 SOUTH ; EXIT 21B off I-295 to get onto I-10 WEST to LAKE CITY).
8. Take I-10 WEST to I-75 SOUTH to TAMPA at EXIT 296A in Lake City.
9. Take I-75 SOUTH to Ft. Myers.