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What is the best route from Philadelphia to Buffalo?

Anonymous

∙ 14y ago

Updated: 10/22/2022

Take I-476 Pennsylvania Turnpike NE Ext (toll) NORTH to I-81 to BINGHAMTON and WILKES-BARRE near Scranton. You want I-81 NORTH to BINGHAMTON.
Take I-81 NORTH through Pennsylvania to I-90 New York State Thruway (toll) at EXIT 25A just north of downtown Syracuse, NY. You want I-90 Thruway (toll) WEST to BUFFALO.
Take I-90 New York State Thruway (toll) WEST to BUFFALO.

Wiki User

∙ 14y ago

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