What is the shortest route from Charleston to Tampa?

Answer 1

If you are talking about Charleston, SC, the route that you would take to I-95 is US-17 SOUTH to I-95 SOUTH. If you are talking about Charleston, WV, the route to I-95 is to take I-77 SOUTH through West Virginia, Virginia and North Carolina to where I-77 ENDS at I-26 in Columbia, SC. At I-26 take I-26 EAST TO I-95 to CHARLESTON. Then take I-26 EAST to I-95 SOUTH to SAVANNAH at EXIT 169A.

From I-95 SOUTH:

1. Take I-95 SOUTH though South Carolina and Georgia to I-295 SOUTH at EXIT 362B in Florida.
2. Take I-295 around Jacksonville, FL to I-10 WEST to LAKE CITY at EXIT 21B.
3. Take I-10 WEST to I-75 SOUTH to TAMPA at EXIT 296A near Lake City.
4. Take I-75 SOUTH to I-275 SOUTH to TAMPA and ST. PETERSBURG at EXIT 274.
5. Take I-275 SOUTH to Tampa.