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If an enzyme is put under certain conditions, including proximity to heavy metals, pH extremes, and temperature extremes, the enzyme will break apart. This means that the enzyme has been denatured, and will no longer work.

It depends on how much the enzyme's shape has changed. This is dependent on what enzyme is in question and what conditions it was put under.

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Q: Can the reaction of an enzyme still take place if it's shape is changed by a heavy metal or the change in it's pH level?
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