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In prokaryotes the DNA floats freely in the cytoplasm.

In eukaryotes the majority of the DNA is contained within an organelle called the nucleus and there is none in the cytoplasm. Smaller amounts of DNA is contained in other organelles (e.g. mitochondria, chloroplasts, ribosomes).

The cytoplasm itself contains no genetic information in either case.

There are many exceptions to the rule in genetics. One of them is that not all inherited characters are determined by genes located in the nucleus. A small minority are controlled by genes located in cell organelles in the cytoplasm i.e. cytoplasmic genes, and these of course are exceptions to the chromosome theory of inheritance. Since they are extrachromosomal (i.e. outside the chromosomes), such genes are not subject to the normal rules of Mendelian heredity.

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