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Thiamine (Vitamin B_1) is an important component of the pyruvate dehydrogenase complex--the enzyme complex which converts pyruvate to acetyl-CoA. This specific reaction is the "Link Reaction" which connects glycolysis and the citric acid cycle.

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Q: Does thiamine play a role in citric acid cycle?
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The citric acid cycle requires co-enzymes from what vitamins?

Vitamins, especially the B vitamins, play extremely important roles in producing cellular energy. Vitamins B2 and B3, for example, supply the major building blocks for substances called flavin adenine dinucleotide (FAD and FADH) and nicotinamide adenine dinucleotide (NAD and NADH) which are critical elements of producing energy in the Krebs cycle as well as a process called oxidative phosphorylation. Thiamine is the cofactor of Thiamine pyrophosphate enzyme (TPP).


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The B vitamins are eight water-soluble vitamins that play important roles in cell metabolism, and are essential to human health and proper cellular function:* Vitamin B1 (thiamine) * Vitamin B2 (riboflavin) * Vitamin B3 (niacin, includes nicotinic acid and nicotinamide) * Vitamin B5 (pantothenic acid) * Vitamin B6 (pyridoxine, pyridoxal, and pyridoxamine) * Vitamin B7 (biotin), also known as vitamin H * Vitamin B9 (folic acid), also, vitamin M * Vitamin B12 (various cobalamins; commonly cyanocobalamin in vitamin supplements) ThiamineThiamine, or thiamin, sometimes called aneurin, is a water-soluble vitamin of the B complex (vitamin B1), whose phosphate derivatives are involved in many cellular processes, especially those of the peripheral nervous system and/or the cardiovascular system.RiboflavinIt is the central component of the cofactors FAD and FMN, and is therefore required by all flavoproteins. As such, vitamin B2 is required for a wide variety of cellular processes. Like the other B vitamins, it plays a key role in energy metabolism, and is required for the metabolism of fats, ketone bodies, carbohydrates, and proteins.NiacinNiacin is a precursor to NADH, NAD, NAD+, NADP and NADPH, which play essential metabolic roles in living cells. Niacin is involved in both DNA repair, and the production of steroid hormones in the adrenal gland.Pantothenic acidPantothenic acid, also called vitamin B5 (a B vitamin), is a water-soluble vitamin required to sustain life (essential nutrient). Pantothenic acid is needed to form coenzyme-A (CoA), and is critical in the metabolism and synthesis of carbohydrates, proteins, and fats.B6 vitaminsPyridoxal phosphate (PLP) is the active form and is a cofactor in many reactions of amino acid metabolism, including transamination, deamination, and decarboxylation. PLP also is necessary for the enzymatic reaction governing the release of glucose from glycogen.BiotinBiotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids. It plays a role in the Citric acid cycle, which is the process by which biochemical energy is generated during aerobic respiration. Biotin not only assists in various metabolic reactions, but also helps to transfer carbon dioxide.Folic acidFolic acid and Folate is essential to numerous bodily functions ranging from nucleotide synthesis to the remethylation of homocysteine. It is especially important during periods of rapid cell division and growth. Both children and adults require folic acid to produce healthy red blood cells and prevent anemia.B12 vitaminsVitamin B12 plays a key role in the normal functioning of the brain and nervous system, and for the formation of blood. It is one of the eight B vitamins. It is normally involved in the metabolism of every cell of the body, especially affecting DNA synthesis and regulation, but also fatty acid synthesis and energy production.


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