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Most DNA Polymerases and RNA polymerases have what is known as "proof-reading activity". This is the ability of the enzymes to check what bases they have added during DNA replication (in the case of DNA Polymerase) or transcription (in the case of RNA Polymerase), and if an error is found, splice it out and replace it with the correct base. The mode of action depends on the enzyme in question - some use endonucleases, and some use exonucleases; some work 5'-3' while others work 3'-5'. Also note that I said MOST polymerases have proof-reading capabilities...there are a few which do not (or don't proof-read very well).

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Q: How are the accuracy of DNA and RNA assured?
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