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A malfunction in the p53 protein can lead to a cell becoming cancerous by allowing damaged cells to replicate without undergoing cell cycle arrest or apoptosis (cell death), leading to the accumulation of mutations and unchecked cell growth, which promotes tumor formation. The p53 protein normally functions to monitor and repair DNA damage or trigger cell death if the damage is irreparable, so a malfunction can disrupt these crucial regulatory mechanisms.

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1y ago

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