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For a recessive sex-linked trait to manifest in women it would have to be in double dose (XaXa) while for men in single dose (XaY). Women carriers would have one of each but would not be affected (XAXa). Knowing this it's quite easy to spot pedigrees where this kind of inheritance occures.

  • Heterozygote mothers (gene carrier) can have sons that are affected (50% chance);
  • Affected mothers have only affected sons (100%);
  • No first generation daughter of an heterozygote mother will be affected but there is a 50% chance that she is a carrier;
  • Affected fathers with normal mothers will have zero sons that are affected but all their daughters will be carriers;
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10y ago
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a disease seen more often in males than females

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Q: How do you recognize a pedigree for an x-linked recessive allele in human beings?
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