The Alpha 1 Antitrypsin Deficiency means that the body does not make enough protein to protect the liver and lungs from damage. AAT is given to patients to help them produce some protein. If the patient smokes they are advised to quit.
Serum protease inhibitor alpha-1-antitrypsin
Alpha-1 Antitrypsin Deficiency is a genetic disorder that is passed along through generations. This is a deficiency in a protein of the lungs and the liver. If left untreated, it can ultimately lead to lung and liver disease.
It is a dietary deficiency disease. It happens when you do not eat the right foods. Not communicable.
peripheral blood vesels
Type 1 diabetes
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Although the wide majority of Alpha 1's are of Northern European decent, most of us are not of one pure race. If he is an Alpha then both of his parents would have to be carriers of the gene. A simple blood test can determine if he was an Alpha and I don't know if that was done. Alpha 1 deficiency can cause either chronic COPD or liver disease. No one knows if Michael Jackson had Alpha-1 Antitrypsin Deficiency. The only source for the claim is Ian Halperin, a writer who did a biography of Jackson. Halperin provided no evidence whatever for this claim, and Jackson's spokesman denied it as "a total fabrication." Alpha-1 is considered rare in African Americans. However, the Alpha-1 Foundation recently awarded a grant to study the high rate of lung disease in African Americans, and to test them for Alpha-1 Antitrypsin Deficiency.
The number of Americans with this deficiency is relatively small, probably no greater than 70,000
People with this type of emphysema have a hereditary deficiency of a blood component, an enzyme inhibitor called alpha-1-antitrypsin
Alpha-1 antitrypsin (AAT) is a condition whereby the body suffers a deficiency of the protein required to protect the liver and the lungs from damage, which may lead to liver diseases or emphysema.
It is thought that every 1:2000 Caucasian births results in someone who is genetically 'alpha-1 antitrypsin deficient'. This puts the potential deficient population in the US at about 100,000 even though only a fraction of that number has been identified. For more information go to the related link below.
Serum protease inhibitor alpha-1-antitrypsin
It is a blood component that breaks down infection-fighting enzymes such as elastase
Alph-1-antitrypsin, produced in the liver, is a protease inhibitor. It inhibits Factor XIa, thrombin, kallikrein, plasmin, and tPA in the coagulation pathway. It is the major inhibitor of FXIa.
Alpha-1 Antitrypsin Deficiency is a genetic disorder that is passed along through generations. This is a deficiency in a protein of the lungs and the liver. If left untreated, it can ultimately lead to lung and liver disease.
The best way is to reduce smoking as smokers chances to get emphysema is much higher than the non-smokers. However, in certain people, it is due to genetic reason (ie: alpha-1-antitrypsin deficiency) which means not much thing can be done to prevent it but some intervention is still possible to reduce the symptoms.
One of the mechanisms is that: Alpha 1 antitrypsin (an alpha 1 globulin) normally inhibits proteases and thus elastases also. Normally; due to negative control on elastases, elastic component of lungs is maintained with proper physical characteristics. The compound does it so by binding with proteases through amino acid methionine at 358 position in its chain. In a smoker; the methionine is oxidised to methionine sulfoxidase; which cannot bind to proteases. As inhibition is released, elastic components of lung start degrading by action of these enzymes. Thus, smoker gets emphysema or other disorders and it causes decrease in vital capacity as distensibility (compliance/stretchability) decreases. Smokers with alpha 1 antitrypsin deficiency have a worse condition. Smoking destroys alveoli and capillaries therefore not as much oxygen can be absorbed by the lungs/body.