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What is the genotype of alpha 1 antitrypsin deficiency?
Alpha-1 Antitrypsin Deficiency is a genetic disorder that is passed along through generations. This is a deficiency in a protein of the lungs and the liver. If left untreated, it can ultimately lead to lung and liver disease.
What is in the FBS that inhibits the trypsin?
Fetal bovine serum (FBS) contains trypsin inhibitors that can interfere with trypsin activity. These inhibitors can bind to and inhibit trypsin, reducing its ability to cleave proteins effectively. It is important to remove or inactivate these inhibitors when using trypsin for cell culture experiments.
What are the properties of the alpha adrenergic receptors?
The alpha adrenergic receptors are located in the effector organs of sympathetic nervous system. They are the most common type of alpha adrenergic receptor. Alpha adrenergic receptors tend to be excitatory. They have a greater affinity for nonepinephrine than epinephrine.
Is beriberi a comunicable or non communicable disease?
It is a dietary deficiency disease. It happens when you do not eat the right foods. Not communicable.
What is alpha 1-1 linkage?
Alpha 1-1 linkage refers to the type of glycosidic bond in which the anomeric carbon atom of one sugar molecule is linked to the hydroxyl group on the carbon atom number 1 of another sugar molecule. This linkage is commonly found in complex polysaccharides like starch and glycogen.
Is alpha 1 anTitrypsin deficiency the same as idiopathic pulmonary fibrosis?
no
Did Michael Jackson have alpha 1 antitrypsin deficiency?
Although the wide majority of Alpha 1's are of Northern European decent, most of us are not of one pure race. If he is an Alpha then both of his parents would have to be carriers of the gene. A simple blood test can determine if he was an Alpha and I don't know if that was done. Alpha 1 deficiency can cause either chronic COPD or liver disease. No one knows if Michael Jackson had Alpha-1 Antitrypsin Deficiency. The only source for the claim is Ian Halperin, a writer who did a biography of Jackson. Halperin provided no evidence whatever for this claim, and Jackson's spokesman denied it as "a total fabrication." Alpha-1 is considered rare in African Americans. However, the Alpha-1 Foundation recently awarded a grant to study the high rate of lung disease in African Americans, and to test them for Alpha-1 Antitrypsin Deficiency.
How many Americans lack alpha-1-antitrypsin?
The number of Americans with this deficiency is relatively small, probably no greater than 70,000
What causes early onset emphysema?
People with this type of emphysema have a hereditary deficiency of a blood component, an enzyme inhibitor called alpha-1-antitrypsin
What is alpha one?
Alpha-1 antitrypsin (AAT) is a condition whereby the body suffers a deficiency of the protein required to protect the liver and the lungs from damage, which may lead to liver diseases or emphysema.
Who discovered alpha 1?
Alpha-1 antitrypsin was discovered by Dr. Laurell and Dr. Eriksson in 1963. They identified it as a serum protein and named it alpha-1-antitrypsin based on its ability to inhibit the enzyme trypsin.
How many people have alpha 1 antitrypsin deficiency?
It is thought that every 1:2000 Caucasian births results in someone who is genetically 'alpha-1 antitrypsin deficient'. This puts the potential deficient population in the US at about 100,000 even though only a fraction of that number has been identified. For more information go to the related link below.
What is Alpha-1-antitrypsin?
It is a blood component that breaks down infection-fighting enzymes such as elastase
What is the genotype of alpha 1 antitrypsin deficiency?
Alpha-1 Antitrypsin Deficiency is a genetic disorder that is passed along through generations. This is a deficiency in a protein of the lungs and the liver. If left untreated, it can ultimately lead to lung and liver disease.
Alpha 1-antitrypsin role in coagulation?
Alph-1-antitrypsin, produced in the liver, is a protease inhibitor. It inhibits Factor XIa, thrombin, kallikrein, plasmin, and tPA in the coagulation pathway. It is the major inhibitor of FXIa.
How can you prevent emphysema?
The best way is to reduce smoking as smokers chances to get emphysema is much higher than the non-smokers. However, in certain people, it is due to genetic reason (ie: alpha-1-antitrypsin deficiency) which means not much thing can be done to prevent it but some intervention is still possible to reduce the symptoms.
How smoking decreases vital capacity?
One of the mechanisms is that: Alpha 1 antitrypsin (an alpha 1 globulin) normally inhibits proteases and thus elastases also. Normally; due to negative control on elastases, elastic component of lungs is maintained with proper physical characteristics. The compound does it so by binding with proteases through amino acid methionine at 358 position in its chain. In a smoker; the methionine is oxidised to methionine sulfoxidase; which cannot bind to proteases. As inhibition is released, elastic components of lung start degrading by action of these enzymes. Thus, smoker gets emphysema or other disorders and it causes decrease in vital capacity as distensibility (compliance/stretchability) decreases. Smokers with alpha 1 antitrypsin deficiency have a worse condition. Smoking destroys alveoli and capillaries therefore not as much oxygen can be absorbed by the lungs/body.
