0
If a mutation happens within a gene how could this alter the protein that is made by the gene?
Wiki User
∙ 14y ago
DNA codes for
proteins
. So, if the DNA is mutated, it directly affects the protein. Two examples of mutations are:
A point mutation. In this situation, one
base pair
(A, T, C, or G) is replaced with a different, incorrect one. When this happens and the DNA is read in order to synthesize a protein, this incorrect base pair can lead to the DNA codon (set of 3 base pairs) that codes for a different base pair than it should have. This causes the protein to have one incorrect amino acid in it. Also, this mutation does not always mutate the protein because some codons code for the same amino acid.
A frame shift mutation. This type is much worse. In this case, a base pair is just inserted in to the
DNA sequence
. When this happens, the entire sequence following it is essentially pushed over one spot. Then, each set of 3 base pairs that would code for an amino acid is shifted so that, instead, you would have something like 2 base pairs and 1 base pair from the codon next to it. This causes every single codon to mutate, which essentially leads to every amino acid being different and therefore, the entire protein being different.
I hope that made sense. Diagrams help.
Wiki User
∙ 11y ago
Wiki User
∙ 14y agoIf a mutation happens within a gene, it could shift the reading frame affecting the mRNA strand and then the amino acid sequence thus conceiving a different protein.
Wiki User
∙ 13y agoBecause DNA determines the amino acid sequence of protein, a mutation might cause a change in one amino acid in a protein.
Wiki User
∙ 10y agomRNA in the both tabel have differen code because of that it would be change the protein shape.
Add your answer:
Earn +20 pts
A mutation that alters a single amino acid within a protein can alter?
the primary, secondary, and tertiary level of a protein structure because once an amino acid is effected by a mutation in a single amino acid it ruins the entire protein on all levels
What type of mutation will the deletion of a DNA nucleotide from a strand of DNA cause?
The DNA sequence of a gene can be altered in a number of ways. Gene mutations have varying effects on health, depending on where they occur and whether they alter the function of essential proteins.The types of mutations include: missense mutation, nonsense mutation, insertion, deletion, duplication, frameshift mutation or repeat expansion.A deletion changes the number of DNA bases by removing a piece of DNA. Small deletions may remove one or a few base pairs within a gene, while larger deletions can remove an entire gene or several neighboring genes. The deleted DNA may alter the function of the resulting protein(s).
What are synonyms of mutation?
Some are change, alter, transform, transmute, etc.
What is mutation.?
A mutation is a permanent change in the DNA sequence of a gene. Mutations in a gene's DNA sequence can alter the amino acid sequence of the protein encoded by the gene. How does this happen? Like words in a sentence, the DNA sequence of each gene determines the amino acid sequence for the protein it encodes. The DNA sequence is interpreted in groups of three nucleotide bases, called codons. Each codon specifies a single amino acid in a protein. butthole
What is point mutation substitution?
When a nitrogen base is substituted for a different one so it may code for a different amino acid. Sometimes substitution still codes for a same amino acid, in which case it becomes a silent mutation, but in other times it may alter the protein entirely.
A mutation that alters a single amino acid within a protein can alter?
the primary, secondary, and tertiary level of a protein structure because once an amino acid is effected by a mutation in a single amino acid it ruins the entire protein on all levels
What is a chromosomal mutation?
mutation is a permanent change in the DNA sequence of a gene and can alter the amino acid sequence of the protein encoded by the gene..
How can a point mutation alter the final structure of a protein?
In a point mutation, one nitrogen base is substituted for the correct base. Since most amino acids can be coded for by more than one codon, there may be no consequence to this mutation. However, sometimes a point mutation results in an incorrect amino acid being added to the amino acid sequence of the protein. This can cause a change in the shape and therefore function of the protein, which can be a harmful mutation. Two genetic disorders caused by a point mutation are cystic fibrosis and sickle cell anemia.
What type of mutation will the deletion of a DNA nucleotide from a strand of DNA cause?
The DNA sequence of a gene can be altered in a number of ways. Gene mutations have varying effects on health, depending on where they occur and whether they alter the function of essential proteins.The types of mutations include: missense mutation, nonsense mutation, insertion, deletion, duplication, frameshift mutation or repeat expansion.A deletion changes the number of DNA bases by removing a piece of DNA. Small deletions may remove one or a few base pairs within a gene, while larger deletions can remove an entire gene or several neighboring genes. The deleted DNA may alter the function of the resulting protein(s).
Why does a denature protein no longer function normally?
the function of each protein is a consequence of its specific shape, which is lost when a protein becomes denatured.The shape of a protein determines its specific function within a cell. Denaturing a protein will alter its shape, thus it will no longer function.
What are synonyms of mutation?
Some are change, alter, transform, transmute, etc.
What is mutation.?
A mutation is a permanent change in the DNA sequence of a gene. Mutations in a gene's DNA sequence can alter the amino acid sequence of the protein encoded by the gene. How does this happen? Like words in a sentence, the DNA sequence of each gene determines the amino acid sequence for the protein it encodes. The DNA sequence is interpreted in groups of three nucleotide bases, called codons. Each codon specifies a single amino acid in a protein. butthole
Do mutations always alter the encoded protein structure and function?
No. Since a mutation in the DNA may not necessarily result in a change to the encoded amino acid in the protein sequence, it is entirely possible. Further, the protein function will likely not change when an amino acid is replaced with one of similar chemical properties. Sometimes it does, sometimes it doesn't. This is the field that molecular evolutionary biologists study.
What is point mutation substitution?
When a nitrogen base is substituted for a different one so it may code for a different amino acid. Sometimes substitution still codes for a same amino acid, in which case it becomes a silent mutation, but in other times it may alter the protein entirely.
Why can some gene mutatuions be harmful while others have no effect?
Let's consider a simple example: protein-coding genes. Mutations, or changes in the DNA sequence of the gene, can alter the amino acid sequence of the protein it codes for, if the new sequence translates into different amino acids. Because the genetic code is degenerate, some amino acids are specified by multiple codons, so some mutations may not alter the amino acid sequence at all. Such mutations, called synonymousmutations, have no affect on the protein. Mutations that alter the amino-acid sequence of the protein, called non-synonymousmutations, may or may not have an affect. Most proteins can tolerate some changes to that sequence and not be significantly affected, but if the sequence change is large enough, or occurs at a critical point so that the structure of the protein is significantly altered, then the protein may become non-functional. If that protein is essential to an organism, such a mutation may be lethal.
How does a mutagen alter a genetic material?
when in the genome there is linear sequence of genes are arranged but when mutation occur in that particular gene which is performing particular job then it definately alter the genetic material from regular work
What is a chromosome mutation and how is it caused?
If you are asking about the change in number of chromosomes, there are many that are non-fatal but many that are. Trisomy 21 has three chromosome #21 (Down's Syndrome) and the person can do OK but is usually developmentally delayed. Others like this are fatal.The DNA sequence of a gene can be altered in a number of ways. Gene mutations have varying effects on health, depending on where they occur and whether they alter the function of essential proteins.The types of mutations include:Missense mutationThis type of mutation is a change in one DNA base pair that results in the substitution of one amino acid for another in the protein made by a gene.Nonsense mutationA nonsense mutation is also a change in one DNA base pair. Instead of substituting one amino acid for another, however, the altered DNA sequence prematurely signals the cell to stop building a protein. This type of mutation results in a shortened protein that may function improperly or not at all.InsertionAn insertion changes the number of DNA bases in a gene by adding a piece of DNA. As a result, the protein made by the gene may not function properly.DeletionA deletion changes the number of DNA bases by removing a piece of DNA. Small deletions may remove one or a few base pairs within a gene, while larger deletions can remove an entire gene or several neighboring genes. The deleted DNA may alter the function of the resulting protein(s).DuplicationA duplication consists of a piece of DNA that is abnormally copied one or more times. This type of mutation may alter the function of the resulting protein.Frameshift mutationThis type of mutation occurs when the addition or loss of DNA bases changes a gene’s reading frame. A reading frame consists of groups of 3 bases that each code for one amino acid. A frameshift mutation shifts the grouping of these bases and changes the code for amino acids. The resulting protein is usually nonfunctional. Insertions, deletions, and duplications can all be frameshift mutations.Repeat expansionNucleotide repeats are short DNA sequences that are repeated a number of times in a row. For example, a trinucleotide repeat is made up of 3-base-pair sequences, and a tetranucleotide repeat is made up of 4-base-pair sequences. A repeat expansion is a mutation that increases the number of times that the short DNA sequence is repeated. This type of mutation can cause the resulting protein to function improperly.
