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It refers to the Rh blood group (the blood group system is named Rh because it was first discovered in rhesus monkeys).

In the Rh blood group, the main antigens are D, C, c, E, and e.

The presence or absence of the D antigen determines whether you are considered Rh negative or positive; Rh positive individuals have D, Rh negative people do not.

Rh negative people are sometimes written as having d (as opposed to D) but this is a misnomer because there is no d antigen; d merely denotes the absence of D (just as in the ABO blood group, type O people do not have an O antigen; they merely lack A and B).

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