Clubbing is a condition that affects the nails in certain people. Besides certain diseases being known to cause it, clubbing's mechanism is caused by a Mendelian dominant trait.
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clubbing is normally referred to a club apperance that appears to the end of fingers. This is normally caused from poor circulation which can be caused from many sources, but the most frequent one is from smoking.
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Even though clubbing is a widely recognized symptom of many diseases the physiological mechanism that actually causes clubbing is not well understood. Current understanding is that these diseases cause http://www.answers.com/topic/vasodilator in the distal circulation which leads to http://www.answers.com/topic/organ-hypertrophy of the tissue of the nailbeds and thus to the clubbed fingernails. Other factors that have been implicated are the local effects of growth factors (such as http://www.answers.com/topic/platelet-derived-growth-factor and http://www.answers.com/topic/hepatocyte-growth-factor) that are usually sequestrated in the pulmonary capillary bed. Many of the conditions associated with clubbing result in shunting across some of the capillary beds in the pulmonary circulation.http://www.answers.com/clubbing See the Related Links for "The aetiology of clubbing and hypertrophic osteoarthropathy." to the bottom for the answer.
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Clubbing of the nails is a symptom of an underlying medical condition, so the treatment involves addressing the root cause. This may include managing heart or lung disease, liver disease, or other conditions contributing to the clubbing. Consult a healthcare provider for proper diagnosis and treatment.
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