PTH is broken down in the body into three different molecular forms: the intact PTH molecule and several smaller fragments which include an amino acid or N-terminal, a midregion or midmolecule, and a carboxyl or C-terminal.
The assay for intact PTH and the N-terminal fragment, which are both measured at the same time, is more accurate in detecting sudden changes in the PTH level. For this reason, the N-terminal PTH assay is used to monitor a patient's response to therapy.
both PTH and mechanical forces work together in bone remodeling. PTH determines when or if bone is to be broken down or formed. Once the PTH determines this then the mechanisms ( osteoblasts and osteoclasts) will begin to build or destroy in bone remodeling :) hope this helps!
Osteoclast
PTH levels are subject to daily variation, ranging from a peak around 2:00 a.m. to a low point around 2:00 p.m.
The function of the parathyroid glands is to secrete parathyroid hormone, which causes the release of the calcium present in bone to extracellular fluid (ECF). The ECF is the fluid found outside cells in all body tissues. PTH does this by activating the production of osteoblasts, special cells of the body involved in the production of bone and slowing down osteoclasts, other specialized cells involved in the removal of bone.
Parathyroid gland secrete parathyroid hormone called PTH. PTH regulates calcium level in the body by transferring calcium from the bone and when body has excess calcium, PTH helps them to deposit into the bone.
PTH
If too much PTH is secreted, the bones release calcium into the bloodstream. Over time, the bones become brittle and more likely to break
The C-terminal PTH assay is used to diagnose the ongoing disturbances in PTH metabolism that occur with secondary and tertiary hyperparathyroidism.
Drugs that decrease PTH include cimetidine and propranolol.
The assay for intact PTH and the N-terminal fragment, which are both measured at the same time, is more accurate in detecting sudden changes in the PTH level. For this reason, the N-terminal PTH assay is used to monitor a patient's response to therapy.
The parathyroid glands produce hormones that regulate calcium levels.Calcitonin produced by the thyroid gland, and PTH produced by the parathyroid gland.
It is the name of the test used to determine parathyroid hormone (PTH). It stands for ImmunoRadioMetric Assay.
http://en.wikipedia.org/wiki/Parathyroid_gland http://www.parathyroid.com/
Hypoparathyroidism. The symptoms can range from quite mild (tingling in the hands, fingers, and around the mouth) to more severe forms of muscle cramps. The most severe symptoms are tetany (severe muscle cramping of the entire body) and convulsions (even though, this is very rare).
Hypoparathyroidism. The symptoms can range from quite mild (tingling in the hands, fingers, and around the mouth) to more severe forms of muscle cramps. The most severe symptoms are tetany (severe muscle cramping of the entire body) and convulsions (even though, this is very rare).
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