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It is called "variola virus" or "Human Pox virus", and Abele (Ah-Beh-Leh) in Farsi (as a symbol of ancient languages).

Variola virus is a DNA virus, classified so because it has a genome wholly made of DNA, in contrast to some other viruses which are RNA ones, such as AIDS virus or Influenza virus.

There are some other germs in the family of pox viruses (family poxviridae), namely cowpox virus (vaccinia virus), sheep pox (capripox) virus, monkeypox virus (a member of orthopox viruses) and avipoxvirus (the agent of fowlpox).

Smallpox has misnomination because it causes a very terrible disease of mankind inspite of the term small.

Fortunately, variola no longer exists in the nature and has been eradicated from the world since 1978 as a result of effective global vaccination. Some limited laboratory sources of this devastating human pox virus are stored in research centers of England and US and Russia for medical research which may be catastrophic if intentionally or unintentionally released to the community. For more information the reader may refer to "Principles and Practice of Infectious Disease" by Mandell, Vol 2, or contact me through m3mahdi@razi.tums.ac.ir.

M. Mahdi Mohammadi, LMD, MPH, PhD, Immunologist

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