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Hypertension represents a common and powerful predisposing factor for cardiovascular disease or events and renal failure. Approximately 90% of patients with end-stage renal disease (ESRD) have a history of hypertension. High blood pressure may initiate renal damage and also increase the rate of progression of renal insufficiency. Persistent high blood pressure represents the early trigger mechanism for renal disease.

The final pathway is represented by progressive sclerosis of glomeruli (Vascular part of nephron). A main role is played by transforming growth factor 1 (TGF1), a multifunctional cytokine that regulates cell growth, differentiation, matrix production, blocks matrix degradation, inducing fibrosis in many tissues, including kidney, blood vessels, lung and heart. High circulating levels of TGF1 can mediate renal fibrosis and loss of function.

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Q: What effects would increased blood pressure have on nephron function?
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list the parts of the nephron and describe the function of each part


What are the parts of a nephron and functions?

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If your blood pressure is too high, as in the case of someone with hypertension, the glomerulus of the nephron can burst rendering that nephron useless. Without a glomerulus, the nephron cannot achieve pressure filtration, which is one of the main functions of the kidney.


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