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Pathogenic prokaryotes release toxins in the body or endospores in the body that leads to a homeostatic imbalance in the body causing disease and possibly death. Prokaryotes have a cell wall and some prokaryotes such as gram-negative bacteria have lipopolysaccarides that are very toxic to the body causing a homeostatic imbalance/disease resulting in death. When you force contact of pathogens to other humans that have developed anti-biotic resistance this pathogen can be extremely contagious and wipe out a portion of the population.

Sources: Look at chapter 27 of your book LOL.

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