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Beta-lactamases are enzymes produced by bacteria. Gram-positive bacteria can produce beta-lactamases. This type of bacteria takes up the crystal violet stain in gram staining.

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Clavulanic acid is an antibiotic, which selectively blocks the betalactamase enzyme. So the amoxicillin is left free to kill the bacteria, which produce betalactamase enzyme. For this advantage, clavulanic acid is added with amoxicillin.


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ceftriaxone is ase third genration antibiotic and having good coverage againast gram positive and grame neative ,while sulbuctem increase its activity against betalactamase producing bcteria.


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