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What is tyrosine kinase receptor dimerization. Receptor polymorphism and dimerization in drug design?
Wiki User
∙ 12y ago
I suppose I would need a better understanding of what you mean by the latter part of the question. Receptors can be influenced by polymorphisms (different "formula" variations that are expressed in populations which influence binding...Ex replacing a neutral amino acid with a positive affects binding correct?....As far as dimerization as it relates to drug design I must first confess that I'm not a pharmacologist... however my guess would be that they would want to make their products multivalent so that they bind multiple TK's so that they are able to dimerize...(this is merely a guess)
Wiki User
∙ 12y ago
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What membrane receptor undergoes dimerization and autophosphorylation?
tyrosine kinase receptor.
The activation of receptor tyrosine kinases is characterized by what?
Dimerization and phosphorylation
The activation of receptor tyrosine kinases is characterized by?
dimerization and phosphorylation.
Growth factor hormones such as insulin bind to which type of receptor?
tyrosine kinase receptor!!
What is the function of receptor proteins?
Receptor proteins are designed so special molecules can bind to them, and send messages to the cell that trigger some sort of reaction within the cell.They are embedded in either the plasma membrane or cytoplasm of a cell, to which a mobile signaling (or "signal") molecule may attach.Sources: http://en.wikipedia.org/wiki/Receptor_proteins
What membrane receptor undergoes dimerization and autophosphorylation?
tyrosine kinase receptor.
The activation of receptor tyrosine kinases is characterized by what?
Dimerization and phosphorylation
The activation of receptor tyrosine kinases is characterized by?
dimerization and phosphorylation.
What is the difference of g-protein receptor system and tyrosine kinase receptor?
Receptor tyrosine kinases do not require the use of second messengers while G protein-coupled receptors need.
Growth factor hormones such as insulin bind to which type of receptor?
tyrosine kinase receptor!!
The receptor for a group of signaling molecules known as growth factors are often?
receptor tyrosine kinases
What has the author J Schlessinger written?
J. Schlessinger has written: 'Cellular signaling by receptor tyrosine kinases'
What are membrane receptors that attach phosphates to specific animo acids in proteins?
called receptor tyrosine-kinases
What Would be inhibited by a drug that specifically blocks the addition of phosphate groups to proteins?
receptor tyrosine kinase activity
BCR-ABL tyrosine kinase receptor?
Is the genetic abnormality which is a characteristic of a haematological malignancy, chronic myeloid leukemia.
Compare two ways that the binding of a signal molecule to a receptor protein causes a change in activity the receiving cell?
1. Insulin binding to insulin receptor tyrosine kinase on hepatocyte: increased glucose uptake, increased glycogen and fatty acid production and decreased catabolism in general (decreased gluconeogenesis, lipolysis, and proteolysis). Insulin binding causes receptor dimerization and self-phosphorylation. Phosphorylated receptor recruits scaffold proteins and downstream target proteins and phosphorylate them. Phosphorylated target proteins serve as kinases and activate or deactivate other proteins by phosphorylation, effecting appropriate effects. 2. Erythropoietin binding to EPO cytokine receptor on Common Myeloid Progenitor cell: eventual differentiation into erythrocyte. Cytokine receptor induces the Jak/STAT pathway resulting in altered gene expression by transcription factors, drastically changing the function and morphology of the cell.
What has the author Joanne Chan written?
Joanne Chan has written: 'Characterizaton of receptor protein-tyrosine kinases, EEK and IRR'
