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BCR-ABL tyrosine kinase receptor?
BCR-ABL is a fusion gene that produces a constitutively active tyrosine kinase receptor, leading to uncontrolled cell proliferation in certain leukemias, notably chronic myeloid leukemia (CML). Targeted therapy with tyrosine kinase inhibitors, like imatinib, is commonly used to block the BCR-ABL signaling pathway and treat these leukemias.
The receptor for a group of signaling molecules known as growth factors are often?
receptor tyrosine kinases
What is Bruton's agammaglobulinemia tyrosine kinase?
It is an enzyme vital for the maturation of B cells
What is the similarity of G-protein receptor system and Tyrosine-kinase receptor system?
both are plasma membrane receptors located at the cell surface's membrane. both are proteins that are hydrophilic and therefore cannot cross the lipid bilayer and requires second messengers to communicate with the nucleus of cells. activation of the receptors will activate other molecules in the activating cascades and the numbers of affected molecules will increase geometrically. however, activation of such receptors will cause desensitization/adaptation of the receptors themselves. the disability to desensitize can result to serious diseases such as cancer. Khairul Abu Bakar 2nd Year Medical Student National Univ.of Ireland, Galway
What Would be inhibited by a drug that specifically blocks the addition of phosphate groups to proteins?
A drug that blocks the addition of phosphate groups to proteins would inhibit protein phosphorylation. This process plays a critical role in cellular signaling pathways, protein activity regulation, and various other cellular processes. Inhibiting phosphorylation can affect cell signaling, gene expression, and overall cell function.
What membrane receptor undergoes dimerization and autophosphorylation?
Receptor tyrosine kinases (RTKs) are membrane receptors that undergo dimerization and autophosphorylation upon ligand binding. This activation leads to the recruitment and activation of downstream signaling molecules in the cell.
Growth factor hormones such as insulin bind to which type of receptor?
tyrosine kinase receptor!!
BCR-ABL tyrosine kinase receptor?
BCR-ABL is a fusion gene that produces a constitutively active tyrosine kinase receptor, leading to uncontrolled cell proliferation in certain leukemias, notably chronic myeloid leukemia (CML). Targeted therapy with tyrosine kinase inhibitors, like imatinib, is commonly used to block the BCR-ABL signaling pathway and treat these leukemias.
What has the author Muriel Viegas written?
Muriel Viegas has written: 'The intrinsic tyrosine kinase activity of the epidermal growth factor receptor is necessary for phospholipase A2 activation'
The receptor for a group of signaling molecules known as growth factors are often?
receptor tyrosine kinases
What is Bruton's agammaglobulinemia tyrosine kinase?
It is an enzyme vital for the maturation of B cells
What happens when tyrosine kinase receptors are activated?
When tyrosine kinase receptors are activated, they trigger a series of signaling pathways within the cell that can lead to various cellular responses, such as cell growth, differentiation, and survival. This activation plays a crucial role in regulating important cellular processes and functions.
What is tyrosine kinase receptor dimerization. Receptor polymorphism and dimerization in drug design?
Tyrosine kinases are present in the membrane as separate entities that are able to dimerize with one another when bound to a ligand...for this reason most TK ligands are multivalent (thus can bind multiple TK's and cluster them with the ability to dimerize for activation...a dimer is simply two TK's together. I suppose I would need a better understanding of what you mean by the latter part of the question. Receptors can be influenced by polymorphisms (different "formula" variations that are expressed in populations which influence binding...Ex replacing a neutral amino acid with a positive affects binding correct?....As far as dimerization as it relates to drug design I must first confess that I'm not a pharmacologist... however my guess would be that they would want to make their products multivalent so that they bind multiple TK's so that they are able to dimerize...(this is merely a guess)
What has the author Tomas Mustelin written?
Tomas Mustelin has written: 'Src family tyrosine kinases in leukocytes' -- subject(s): Genes, src, Genetics, Leucocytes, Leukocytes, Metabolism, Physiology, Protein-tyrosine kinase
In mammals g protein coupled receptors play a major role in mediating effects of various hormones not through?
activation of tyrosine kinase activity
What is the function of receptor proteins?
Receptor proteins are designed so special molecules can bind to them, and send messages to the cell that trigger some sort of reaction within the cell.They are embedded in either the plasma membrane or cytoplasm of a cell, to which a mobile signaling (or "signal") molecule may attach.Sources: http://en.wikipedia.org/wiki/Receptor_proteins
What has the author Spencer Bruce Gibson written?
Spencer Bruce Gibson has written: 'Role of the TEC family tyrosine kinase EMT in T cell activation'
