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What antipsychotic drug may be associated with agranulocytosis?
Agranulocytosis has been associated with clozapine. This is a potentially fatal reaction, but can be prevented with careful monitoring of the white blood count.
What is agranulocytosis?
An acute condition marked by severe depression of the bone marrow, which produces white blood cells, and by prostration, chills, swollen neck, and sore throat sometimes with local ulceration.
What is the meaning of lymphocytes granulocytopenia?
Granulocytopenia-- A condition characterized by a deficiency of white blood cells.
What has the author Suzanne Leah Iverson written?
Suzanne Leah Iverson has written: 'In vitro and in vivo investigations into idiosyncratic drug reactions: the role of reactive metabolites produced by the target tissue in terbinafine-induced cholestatic hepatitis and antipsychotic-induced agranulocytosis'
What precautions should be taken with atypical antipsychotic drugs?
Although the atypical antipsychotics are generally safe, clozapine has been associated with severe agranulocytosis, a shortage of white blood cells.
What is the contraindications of carbimazole?
Carbimazole is contraindicated in patients with a known hypersensitivity to the drug or its components. It should also be avoided in individuals with severe liver dysfunction, as it can exacerbate liver issues. Additionally, it is not recommended during pregnancy and breastfeeding due to potential risks to the fetus or infant. Regular monitoring of blood counts is essential, as carbimazole can cause agranulocytosis in some patients.
What does it mean when absolute granulocytes is 0.0?
An absolute granulocyte count of 0.0 indicates a severe deficiency of granulocytes, a type of white blood cell crucial for the immune response. This condition, known as agranulocytosis, can result from various factors, including bone marrow disorders, certain medications, or autoimmune diseases. Patients with this condition are at a significantly increased risk of infections due to their weakened immune system. Immediate medical evaluation is essential to determine the underlying cause and initiate appropriate treatment.
What to monitor for a patient taking chlorptomazine?
When monitoring a patient taking chlorpromazine, it's essential to assess for extrapyramidal symptoms (EPS), such as tremors or rigidity, and monitor for signs of sedation or drowsiness. Additionally, evaluate for potential side effects like weight gain, metabolic changes, and anticholinergic effects. Regularly check blood pressure, as chlorpromazine can cause orthostatic hypotension, and conduct routine blood tests to monitor for agranulocytosis or other hematological changes. Always ensure kidney and liver functions are assessed, given the drug's metabolism and excretion pathways.
Why cant you lay in a tanning bed while taking sulfamethoxazole tmp?
This is a combination of Sulfamethoxazole with Trimethoprim used to treat bacterial infections.About 10 % patients areallergicto it. (Sulfa drug.) So with so many better alternative antimicrobial drugs in hand, doctors avoid using this combination. Apart from drug induced rash, 'which mayaggravatein sun light', patient can have many reactions, though rare, like Agranulocytosis, Steven Johnson syndrome,Erythemamultiform e, Exfoliative dermatitis. So better avoid this drug above 5 years and below six months of age.
Why would a pt be precribed Haldol over Clozail?
A patient may be prescribed Haldol (haloperidol) over Clozaril (clozapine) for several reasons, including Haldol's effectiveness for acute agitation and its relatively lower risk of agranulocytosis, a severe side effect associated with Clozaril. Haldol is also typically less expensive and easier to monitor in terms of side effects, making it a more accessible option for many patients. Additionally, if the patient has not shown a good response to atypical antipsychotics or has a history of treatment non-compliance, Haldol may be favored for its established efficacy in certain situations.
The granulocyte percent in your complete blood count is high what does this mean?
The normal range for granulocyte percentage is 45.5 - 79.7%, which translates into a normal granulocyte count of 2.2 - 8.8 x 10^3/uL. Granulocytopenia is an abnormally low concentration of granulocytes in the blood. This condition reduces the body's resistance to many infections. Closely-related terms include agranulocytosis (no granulocytes at all) and neutropenia (deficiency of neutrophil granulocytes). Transfusion of granulocytes would have been a solution to the problem. However, granulocytes live only ~10 hours in the circulation (for days in spleen or other tissue), which gives a very short-lasting effect. In addition, there are many complications of such a procedure. If you have a high percentage be happy!!!cheers
What are side effects of Sultamicillin?
This is the dtailed description of side effects of sultamicillin nLocal (injection): Pain at injection site and thrombophlebitis in IV administration. nGastrointestinal system: Stomatitis, tongue discoloration, gastritis, diarrhea, enterocolitis, pseudomembranous colitis. nSkin and soft tissue: Skin rash, itching, urticaria, erythema multiforme and rarely, exfoliative dermatitis and some hypersentivity reactions. nHematological: Agranulocytosis and decreases in hemoglobin, hematocrit, erythrocyte, leucocyte, lymphocyte and platelet or increases in lymphocyte, monocyte, eosinophilia and platelet; these findings are reversible and return to normal upon discontinuation of therapy. nLaboratory findings: Increases in SGOT, SGPT, LDH, alkaline phosphatase, BUN and serum creatinine and decreases in serum albumin and total protein. Erythrocyte and hyaline casts can be seen in urine.
