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The oral cavity is colonized by microorganisms from the surrounding environment within and hour after a human is born. Initially the microbiota cnsists mostly of the genera streptococcus, Neisseria, Actinomces, Veillonella and Lactobacillus. When first teeth erupt, anerobes like Prevotella and Fusobacterium become dominant due to the anoxic conditions. As the teeth grow, Streptococcus parasanguis and S. mutans attach to their enamel surfaces; S. salivarius attaches to the buccal and gingival epithelial surface and colonize the saliva. And some times semen.

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