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Phosopholipids have both a hydrophilic (water loving) and hydrophobic (water hating) region. This enables them to effectively make a barrier between the fluid inside and outside of the cell.

The heads of phospholipids are hydrophilic - and so form the surfaces of the membrane, with their hydrophobic (lipid) tails facing inwards.

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The 'head' of a phospholipid is hydrophilic (attracted to water) whereas the hydrophobic 'tails' repel water. The hydrophillic head contains the negatively charged phosphate group, and may contain other polar groups. The hydrophobic tail usually consists of long fatty acid hydrocarbon chains. When placed in water, phospholipids form a variety of structures depending on the specific properties of the phospholipid. These specific properties allow phospholipids to play an important role in the phospholipid bilayer. In biological systems, the phospholipids often occur with other molecules (proteins, glycolipids, cholesterol) in a bilayer such as a cell membrane. Lipid bilayers occur when hydrophobic tails line up against one another, forming a membrane with hydrophilic heads on both sides facing the water.


It is polar, which allows for unique characteristics

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Q: What makes phospholipid molecules uniquely suited to their role in membrane structure?
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