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You can inhibit a receptor by either of 2 ways, one being specific one being not so specific. First of all if you have kinases they have a DNA binding domain as well as a catalytic region and ATP region.
First you have to identify what you cell has for receptors this may be difficult because .01% of the cells mass are these receptors. Most identified by recomiant DNA, so you can find them by there DNA binding conserved sequence. Not all of them also have to be on the surface some maybe in the cytosol of the protien.
So you can make a specific inhibitors for there receptor domain because these are specific. For cancer you want a dirty inhibitor to inhibit a lot of kinases.
What else can I help you with?
Which molecule covers the binding site?
Proteins can cover the binding site of a receptor and prevent another molecule from binding to it. This interaction can inhibit the receptor's activity and affect cellular signaling pathways.
Neurotransmitters bind to specific proteins on the postsynaptic membrane called?
Neurotransmitters bind to specific proteins on the postsynaptic membrane called receptors. These receptors initiate a series of events that can either excite or inhibit the firing of the postsynaptic neuron.
Which factor would most likely interfere with the binding of a ligand to an intracellular receptor?
The presence of other molecules competing for binding to the receptor would most likely interfere with the binding of a ligand to an intracellular receptor. The receptor may also be in an incorrect conformational state that prevents ligand binding. Lastly, alterations in the receptor's structure due to mutations could interfere with ligand binding.
What is the importance of Receptor-mediated Endocytosis in the genetic disorder Familial Hyper-Cholesterolemia?
In mammalian cells, the LDL (low density lipoprotein) receptor transports cholesterol into the cell via receptor-mediated endocytosis. The cholesterol is then used by the cell for various metabolic functions and the receptor is recycled to the plasma membrane.In patients suffering from Familial Hypercholesterolemia, the genes encoding the LDL receptor are mutated, as a result of which cholesterol is unable to bind to the LDL receptor. This leads to accumulation of cholesterol in the circulation, hence causing disease. Patients suffering from this disease are treated using drugs called Statins, which inhibit an important enzyme involved in cholesterol biosynthesis.
What would be least affected by defective receptor proteins on a cell membrane?
The transport of nutrients and waste across the cell membrane would be least affected by defective receptor proteins. This is because transport proteins, not receptor proteins, are primarily responsible for moving molecules across the cell membrane.
What are the effects of dopamine receptor antagonists?
They inhibit the expression of dopamine.
Which molecule covers the binding site?
Proteins can cover the binding site of a receptor and prevent another molecule from binding to it. This interaction can inhibit the receptor's activity and affect cellular signaling pathways.
How a drug interacts with a receptor?
A drug interacts with a receptor by binding to specific sites on the receptor, leading to changes in the conformation or activity of the receptor. This interaction can either activate or inhibit the receptor's function, ultimately affecting downstream signaling pathways and physiological responses within the body. The strength and specificity of this interaction determine the drug's effectiveness and potential side effects.
How would caffeine binding to an adenosine receptor affect the activity inside the neuron?
Adenosine receptors stick through the neuron membrane, so that part of them are on the inside and part is on the outside of the cell. Now, when adenosine, a natural chemical in the body, attaches to the adenosine receptor it shifts the shape of the receptor, this shift reaches all the way to the part on the inside of the cell, and causes the receptor to release attached molecules called G-proteins. These g-proteins now float around the inside of the cell and have all sorts of effects, in this case, to inhibit the neuron. Caffeine also binds to the adenosine receptor, but it doesn't activate the receptor. This means that the receptor is totally shut down, and can't work to inhibit the neuron any more. The end effect is to allow the neuron to be more active than it was before the caffeine.
What are anticholinergics?
Anticholinergics are a class of medications that inhibit parasympathetic nerve impulses by selectively blocking the binding of the neurotransmitter acetylcholine to its receptor in nerve cells.
Neurotransmitters bind to specific proteins on the postsynaptic membrane called?
Neurotransmitters bind to specific proteins on the postsynaptic membrane called receptors. These receptors initiate a series of events that can either excite or inhibit the firing of the postsynaptic neuron.
A receptor that contains many mechanically gated ion channels would function best as?
tactile receptor
How would you change the pA2 for a drug-receptor pair?
The only way to change the pA2 would be to alter the nature of the receptor, because the pA2 is essentially a measurement of the affinity of the antagonist drug for the receptor. So, in order to change this value, one would need to change the receptor in a way that changes the binding affinity of the drug.
What happens to ACh once it has bound to its receptor?
Once acetylcholine (ACh) binds to its receptor, it can either stimulate or inhibit the activity of the cell. This activation triggers a cellular response, such as muscle contraction or nerve cell communication. After its action, ACh is rapidly broken down by the enzyme acetylcholinesterase to terminate the signal.
Which factor would most likely interfere with the binding of a ligand to an intracellular receptor?
The presence of other molecules competing for binding to the receptor would most likely interfere with the binding of a ligand to an intracellular receptor. The receptor may also be in an incorrect conformational state that prevents ligand binding. Lastly, alterations in the receptor's structure due to mutations could interfere with ligand binding.
Can you write a sentence using inhibit?
The antibiotic was prescribed by his physician in the hopes that the medication would inhibit the growth and expansion of the infection .
Why Fresh frozen plasma is given to patients with dengue instead of platelet?
fresh frozen plasma by Fc receptor blockade will inhibit immune mediated destruction of platelets and thereby increase the platelet count
