0
You can inhibit a receptor by either of 2 ways, one being specific one being not so specific. First of all if you have kinases they have a DNA binding domain as well as a catalytic region and ATP region.
First you have to identify what you cell has for receptors this may be difficult because .01% of the cells mass are these receptors. Most identified by recomiant DNA, so you can find them by there DNA binding conserved sequence. Not all of them also have to be on the surface some maybe in the cytosol of the protien.
So you can make a specific inhibitors for there receptor domain because these are specific. For cancer you want a dirty inhibitor to inhibit a lot of kinases.
Wiki User
∙ 14y ago
Add your answer:
Earn +20 pts
What is the importance of Receptor-mediated Endocytosis in the genetic disorder Familial Hyper-Cholesterolemia?
In mammalian cells, the LDL (low density lipoprotein) receptor transports cholesterol into the cell via receptor-mediated endocytosis. The cholesterol is then used by the cell for various metabolic functions and the receptor is recycled to the plasma membrane.In patients suffering from Familial Hypercholesterolemia, the genes encoding the LDL receptor are mutated, as a result of which cholesterol is unable to bind to the LDL receptor. This leads to accumulation of cholesterol in the circulation, hence causing disease. Patients suffering from this disease are treated using drugs called Statins, which inhibit an important enzyme involved in cholesterol biosynthesis.
What are important tissue receptor tumor markers?
estrogen receptor, progesterone receptor, interleukin-2 receptor, and epidermal growth factor receptor.
What is serpentine receptor?
A serpentine receptor is a receptor in the cell membrane that plays a role in signal transduction.
What would be least affected by defective receptor proteins on a cell membrane?
diffusion
What would happen if a hormone receptor did not bind to the right site?
I'm assuming you're asking what would happen if a receptor did not bind the proper hormone. The answer is a complex one because binding to a receptor does not necessarily mean that the receptor will be activated. Sometimes binding causes receptor inhibition; other times it can mean that the properties of the receptor change so that other hormones have an easier/harder time binding and activating it. But for the sake of giving an answer, let's say that we want to know what happens if a hormone binds and activates the wrong receptor. That answer is a relatively simple one: in most cases, the same events would take place that normally happen when the correct hormone binds the receptor. Let's take an example of a relatively uncommon cause of hypertension called hypertension exacerbated in pregnancy. In this condition, there's a mutation in the receptor for the hormone aldosterone that allows other hormones besides aldosterone (eg, progesterone) to bind it and activate it. When progesterone levels are high, as in pregnancy, the extra progesterone binds and heavily activates the aldosterone receptor, and the receptor essentially "thinks" that aldosterone has bound. So the action of progesterone at the aldosterone receptor are the same as aldosterone itself; since aldosterone is a major contributor to blood pressure, blood pressure increases to very high levels.
What are the effects of dopamine receptor antagonists?
They inhibit the expression of dopamine.
How would caffeine binding to an adenosine receptor affect the activity inside the neuron?
Adenosine receptors stick through the neuron membrane, so that part of them are on the inside and part is on the outside of the cell. Now, when adenosine, a natural chemical in the body, attaches to the adenosine receptor it shifts the shape of the receptor, this shift reaches all the way to the part on the inside of the cell, and causes the receptor to release attached molecules called G-proteins. These g-proteins now float around the inside of the cell and have all sorts of effects, in this case, to inhibit the neuron. Caffeine also binds to the adenosine receptor, but it doesn't activate the receptor. This means that the receptor is totally shut down, and can't work to inhibit the neuron any more. The end effect is to allow the neuron to be more active than it was before the caffeine.
What are anticholinergics?
Anticholinergics are a class of medications that inhibit parasympathetic nerve impulses by selectively blocking the binding of the neurotransmitter acetylcholine to its receptor in nerve cells.
Can you write a sentence using inhibit?
The medication is designed to inhibit the growth of bacteria in the body.
A receptor that contains many mechanically gated ion channels would function best as?
tactile receptor
How would you change the pA2 for a drug-receptor pair?
The only way to change the pA2 would be to alter the nature of the receptor, because the pA2 is essentially a measurement of the affinity of the antagonist drug for the receptor. So, in order to change this value, one would need to change the receptor in a way that changes the binding affinity of the drug.
What is the importance of Receptor-mediated Endocytosis in the genetic disorder Familial Hyper-Cholesterolemia?
In mammalian cells, the LDL (low density lipoprotein) receptor transports cholesterol into the cell via receptor-mediated endocytosis. The cholesterol is then used by the cell for various metabolic functions and the receptor is recycled to the plasma membrane.In patients suffering from Familial Hypercholesterolemia, the genes encoding the LDL receptor are mutated, as a result of which cholesterol is unable to bind to the LDL receptor. This leads to accumulation of cholesterol in the circulation, hence causing disease. Patients suffering from this disease are treated using drugs called Statins, which inhibit an important enzyme involved in cholesterol biosynthesis.
Why Fresh frozen plasma is given to patients with dengue instead of platelet?
fresh frozen plasma by Fc receptor blockade will inhibit immune mediated destruction of platelets and thereby increase the platelet count
What do D cells secrete?
D-cells, or Delta cells, can be found in the stomach, intestine, or Islets of Langerhans (the hormone producing regions of the pancreas which also produce glucagon and insulin). Delta cells produce somatostatin, a regulatory hormone. When somatostatin is released it interacts with specialized receptor cells, these cells control the production of other hormones. Somatostatin coming in contact with a somatostatin receptor will inhibit the production of hormones that receptor controls.
What are important tissue receptor tumor markers?
estrogen receptor, progesterone receptor, interleukin-2 receptor, and epidermal growth factor receptor.
Which receives signals a fluid mosaic model or a receptor?
a receptor
Is inhibited a verb?
Inhibited is not a verb, it's an adverb. Inhibit would be the verb.
