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The phospholipid bilayer is semipermeable, meaning in cases other than bulk transport-endocytosis&exocytosis-, it does not compromise its own integrity to allow molecules to enter. The molecules that can most easily diffuse through a cell membrane are small, nonpolar molecules such as N2, O2, and CO2. Ions and polar molecules will have a difficult time crossing the membrane even if they are small because of the middle, hydrophobic layer. They can still pass through, just not as easily. Large molecules, however, cannot pass through the membrane due to their size, regardless or their polarization, and so they rely on those proteins embedded in the bilayer to transport them across (or, in some cases, endocytosis, which is when the cell membrane forms a kind of pocket - looks like a little mouth- and just engulfs the molecules). In this way the proteins are the only gap in what you could imagine as a sort of very fine and very picky filter. Larger molecules cannot get through the mesh of the filter and so they need to be recognized and passed through by those helpful little proteins.

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16y ago
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1mo ago

Big molecules cannot pass through the cell wall because the cell wall is a rigid structure made of cellulose or other materials that restrict the movement of large molecules. This selective barrier helps protect the cell from harmful substances and maintain its internal environment. Instead, large molecules are typically transported into and out of the cell through specific transport proteins or processes.

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8y ago

Because they are large. Hard to diffuse and toxic potential

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8y ago

Cell membranes arepartially permeable. They do not allow laarge molecules to pass

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11y ago

because it is to big

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Q: Why can't big molecules pass through cell wall?
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Molecules can pass through the cell membrane of the human cell?

Yes, molecules can pass through the cell membrane of human cells through various mechanisms such as simple diffusion, facilitated diffusion, or active transport. The size, polarity, and concentration gradient of the molecule influence how it crosses the cell membrane.


What is the process by which molecules of sugar pass through an animal cell membrane to replenish the cell's lack of sugar is?

The process by which molecules of sugar pass through an animal cell membrane is called facilitated diffusion. In this process, sugar molecules move across the cell membrane with the help of specific transport proteins. These transport proteins create channels for the sugar molecules to pass through, allowing them to replenish the cell's supply of sugar.


What is meant by cell membrane is semipermeable?

It allows only certain molecules to pass through.


How do you large molecules and ions pass through the cell membrane?

Large molecules and ions pass through the cell membrane through processes such as facilitated diffusion, active transport, endocytosis, and exocytosis. Facilitated diffusion involves the use of specific transport proteins in the membrane, while active transport requires energy to move molecules against their concentration gradient. Endocytosis and exocytosis involve the engulfing and releasing of large molecules by the cell membrane, respectively.


State one factor that influences which molecules can pass through the cell membrane?

One factor that influences which molecules can pass through the cell membrane is the molecule's size. Smaller molecules are able to pass through the membrane more easily than larger molecules.

Related questions

Why cant big molecules pass through wall guts?

The cell walls of the intestinal cells do not allow the passage of large molecules through them; in addition, the tight junctions between the cells blocks the transfer of large molecules through the interstitial space.


Molecules can pass through the cell membrane of the human cell?

Yes, molecules can pass through the cell membrane of human cells through various mechanisms such as simple diffusion, facilitated diffusion, or active transport. The size, polarity, and concentration gradient of the molecule influence how it crosses the cell membrane.


Do chemicals pass in and out of a cell through openings of the nucleus?

No they pass through the cell membrane. The cell membrane is selectively permeable to ions and organic molecules


How can polar molecules pass through cell membranes?

Through facilitated diffusion


What part of the cell membrane allows small molecules to pass through?

the cell membrane


What kind of substance cannot pass through the cell membrane?

lipids, and ribosomeslipids


What is the process by which molecules of sugar pass through an animal cell membrane to replenish the cell's lack of sugar is?

The process by which molecules of sugar pass through an animal cell membrane is called facilitated diffusion. In this process, sugar molecules move across the cell membrane with the help of specific transport proteins. These transport proteins create channels for the sugar molecules to pass through, allowing them to replenish the cell's supply of sugar.


What is meant by cell membrane is semipermeable?

It allows only certain molecules to pass through.


How do you large molecules and ions pass through the cell membrane?

Large molecules and ions pass through the cell membrane through processes such as facilitated diffusion, active transport, endocytosis, and exocytosis. Facilitated diffusion involves the use of specific transport proteins in the membrane, while active transport requires energy to move molecules against their concentration gradient. Endocytosis and exocytosis involve the engulfing and releasing of large molecules by the cell membrane, respectively.


In fact polar molecules are unable to go across unless?

In fact, polar molecules can pass through cell membranes with the help of specific transport proteins that facilitate their movement. These transport proteins act as channels or carriers to allow polar molecules to cross the hydrophobic membrane. Therefore, polar molecules can indeed pass through cell membranes under certain conditions.


State one factor that influences which molecules can pass through the cell membrane?

One factor that influences which molecules can pass through the cell membrane is the molecule's size. Smaller molecules are able to pass through the membrane more easily than larger molecules.


What allows water molecules to pass through?

Water molecules are able to pass through cell membranes via specialized proteins called aquaporins. Aquaporins facilitate the movement of water across membranes by creating a channel for water molecules to pass through while preventing other molecules from entering. This selective permeability helps to regulate the flow of water in and out of cells.