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You should avoid doing that as Plutonium is considered to be highly toxic, perhaps the most toxic element known.

Plutonium 239 has a half life of 24,100 years, which is not all that long. A fist full of material (less than critical mass!) would probably give you radiation poisoning. More than critical mass would, of course, result in a chain reaction, spewing out lots of nasty short lived fissile byproducts, and producing a squid type blast equivalent to perhaps 20 sticks of TNT. That would be awkward. Then again, if you contained a critical mass of this material (about 14 pounds), you could get a really decent detonation--big enough to level a small city, as with the Fat Man bomb dropped on Nagasaki back in 1945. The heat and pressure from that, if you were close by, would pretty much vaporize you and ionize (strip the electrons off) the vapors.

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