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HCTZ will increase the reabsorption of ions like sodium and lithium. For this reason, your doctor should consider reducing administration of Lithium by 50-75%. You should also monitor for toxic effects of Lithium, which can develop slowly but with long-term use of Lithium. There is a long list of symptoms from toxicity; these would include mania and muscle rigidity.

Lithium has a Black Box warning that says that Lithium toxicity can occur even at therapeutic doses and that a patient need to visit his or her doctor and get serum Lithium levels to make sure that Lithium levels are adequate for treatment of their disorder. I would take the FDA up on their suggestion.

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12y ago

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