Three: 1.5, 6.35, 15.2 (see Schiller J., Arnhold J., Schwinn J., Sprinz H., Brede O., Arnold K., Free Rad. Res., 1999, 30: 45ff)
two scientists named Wiedemann and Schmid
It has two ionizable groups - the NH2 gp can be protonated and the COOH gp can be deprotonated. Some amino acids with ionisable side chains can have three pKa values
The pKa value for sodium bicarbonate (NaHCO3) is 10.3. This provides a measure of the acid strength of bicarbonate. People often make the mistake of reporting the pKa value of 6.3 for bicarbonate. However, that is the pKa value of carbonic acid (not bicarbonate). It relates to the ease of the first deprotonation of carbonic acid to form bicarbonate. The pKa of bicarbonate relates to the deportation of bicarbonate to form carbonate. This distinction is important, since carbonic acid has two pKa's, the higher of which represents that second deprotonation.
There are no accurate pKa value of these two, extremely STRONG acids, any value of >> 1000 (up to >> 1.0*10+9) will do.
As expected from Inductive(/hypercojugative) as well as ortho effect the basicity order should be: ortho-toluidine>para-toluidine>meta-toluidine. But, experimental order is: para-toluidine(Pka=5.12)>meta-toluidine(Pka=4.69)>ortho-toluidine(Pka=4.39).The order of basicity is explained by two opposing effects :i) inductive effect ii) Stability of the conjugate base. Here 2nd factor is more significant for ortho-toluidine & 1st factor is important for para-toluidine. For ortho-toluidine the conjugate base [o-MeC6H4NH3+] is destabilized by steric interaction between -NH3+ & -Me(at ortho). This desatabilization is absent with para-toluidine & meta-toluidine.Tha's why basicity of: ortho-toluidine(Pka=4.39)
two scientists named Wiedemann and Schmid
There are two answers: bicarbonate has two pKa's - because bicarbonate can gain a proton to become carbonic acid or lose a proton to become carbonate. Two reactions; two pKa's. The pKa for bicarbonate carbonic acid reaction is 6.4 The pKa for bicarbonate carbonate reaction is 10.3 Both pKa's are temperature sensitive.
It has two ionizable groups - the NH2 gp can be protonated and the COOH gp can be deprotonated. Some amino acids with ionisable side chains can have three pKa values
The pKa value for sodium bicarbonate (NaHCO3) is 10.3. This provides a measure of the acid strength of bicarbonate. People often make the mistake of reporting the pKa value of 6.3 for bicarbonate. However, that is the pKa value of carbonic acid (not bicarbonate). It relates to the ease of the first deprotonation of carbonic acid to form bicarbonate. The pKa of bicarbonate relates to the deportation of bicarbonate to form carbonate. This distinction is important, since carbonic acid has two pKa's, the higher of which represents that second deprotonation.
There are no accurate pKa value of these two, extremely STRONG acids, any value of >> 1000 (up to >> 1.0*10+9) will do.
Clindamycin phosphate has two acidic protons with pK1 = 0.964 and pK2 = 6.081.
one or two or three??? one or two or three???
Two and three fourths of anything is 2¾ or 2.75
Still three.
One for "three" and two for "hundred".
three
there are three two thirds in two