For Sn1 reaction the rate usually increases due to steric acceleration. For example the more methyl groups a compound has i.e the more tertiary it is the faster the rate of reaction will be for an Sn1 reaction.
6
2
chair form as the steric repulsions is minimum
When an atom comes too close to another atom, their electron clouds overlap and repel, this state is unfavorable and is characterized by higher energy.
steric number of an atom(for example the N of NH4) within a compound is calculated by adding up the number of atoms bonded to that atom(H's bonded to the N) plus the number of lone electron pairs (in this case none, because N's 2p shell is now full, rendering it a stable molecule). This gives NH4 a steric number of four. The positive charge comes from the additonal H+
Due to the steric crowding the tetrahedral inter-mediate can't be form and thus esterification can't take place;this is called steric retardation.
The structures and properties can be used to describe the relation between a steric hindrance and reactivity.
6
2
chair form as the steric repulsions is minimum
pharmacophore
Van der Waals strain is one example
because it bubbles upbecause it changes colour
3 (2 bonding sites & 1 lone pair)
The react to form zinc sterate and water
When an atom comes too close to another atom, their electron clouds overlap and repel, this state is unfavorable and is characterized by higher energy.
In the bicyclic system, a bulky group can be added to position 6. This creates a steric shield which leads to steric hindrance. The beta-lactam ring is hence more protected and the drug can become more resistant to beta-lactamases of bacteria.