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Is an ionized drug more lipophilic or less lipophilic?
An ionized drug is generally less lipophilic than its non-ionized form. This is because ionization usually results in the drug having a greater affinity for water rather than lipid-based environments.
What is lipophilic?
Lipophilic refers to substances or molecules that are attracted to and able to dissolve in fats, oils, and lipids. This term is often used in the context of pharmaceuticals to describe substances that have an affinity for fatty tissues in the body.
What are the differences between 'lipophilic' and 'hydrophobic'?
Lipophilic refers to substances that are soluble in fats and oils, while hydrophobic refers to substances that repel or do not mix with water. Lipophilic compounds interact well with lipids, while hydrophobic compounds avoid water and tend to aggregate with each other. Both terms relate to the affinity of a substance for specific types of solvents.
What is the solubility definition?
Solubility is a physical property of each chemical and describes how well it will dissociate into a given solvent. Most chemicals are evaluated for two types of solubility - aqueous and lipophilic. Aqueous solubility is the ability of the chemical to dissolve or mix into water. Lipophilic solubility is the ability of the chemical to dissolve or mix into a hydrophobic organic solvent such as ethanol.Solubility is the ability of a substance to dissolve in a specific solvent.
The lipophilic tail of a surfactant molecule is considered to be?
The lipophilic tail of a surfactant molecule is considered to be hydrophobic, meaning it repels water and is attracted to nonpolar substances such as oil or grease. This allows the surfactant to interact with both water and oil, helping to emulsify them and form stable mixtures.
What is the nature of solute?
the nature of interaction depends on whether they are lipophilic or hydrophilic. if both are hydorphilic ionic interaction, both lipophilic hydrogen bonding. ionic if lipophilic-hydrophilic.
What is the nature of solute-solvent interaction?
the nature of interaction depends on whether they are lipophilic or hydrophilic. if both are hydorphilic ionic interaction, both lipophilic hydrogen bonding. ionic if lipophilic-hydrophilic.
What kinds of drug need to be lipophilic?
Drugs which are administered percutaneously, sublingually, or have to cross the blood brain barrier have to be lipophilic.
Why is Xenon lipophilic?
Yes. Xenon is lipophilic and exhibits affinity for cavities in macromolecular interiors. Xenon's lipophilic behavior has been shown from its partition with long-chain hydrocarbons and from its in vitro and in vivo partition with fatty tissue.
Can you explain hydrophilic lipophilic?
Hydrophilic means something that is attracted to or absorbed by water. Lipophilic is something that is attracted to or absorbed by fat.
Are steroids lipophilic?
Yup. They sure are.
Does all non polar molecules are lipophilic?
Not all nonpolar molecules are lipophilic, but most lipophilic molecules tend to be nonpolar. Lipophilic molecules are attracted to fats and oils, so they typically do not mix well with water. Nonpolar molecules lack a significant difference in electronegativity and, as a result, do not easily dissolve in water.
Is an ionized drug more lipophilic or less lipophilic?
An ionized drug is generally less lipophilic than its non-ionized form. This is because ionization usually results in the drug having a greater affinity for water rather than lipid-based environments.
What is lipophilic?
Lipophilic refers to substances or molecules that are attracted to and able to dissolve in fats, oils, and lipids. This term is often used in the context of pharmaceuticals to describe substances that have an affinity for fatty tissues in the body.
Which pesticides are most lipophilic?
Organochlorine pesticides, such as DDT and chlordane, are known to be highly lipophilic. These compounds tend to accumulate in fatty tissues due to their molecular structure, which can lead to bioaccumulation in organisms within the food chain.
Is epinephrine lipophilic?
slightly log P of 1.35 is barely cutting it
Why are lipophilic viruses easier to kill?
Lipophilic viruses require the lipid (fatty) envelope to remain active ("live"*), and the fatty layer can be destroyed by alcohol. Non-lipophilic viruses do not require this fatty envelope, and the protein layer (capsid) is more resistant to alcohol. *Note: viruses are not actually alive, they are only genetic codes with 1 or 2 (lipophilic) protective layers. Biologists call "live" viruses *active* and "dead" viruses *inactive* or *inactivated*.
