pKa1 = 2.16
pKa2 = 8.05
Ref: Newton, D.W., Murray, w.j., Lovell, M.W. pKa Determination of benzhydrylpiperazine antihistamines in aqueous and aqueous methanol solutions (1982) Journal of Pharmaceutical Scienses 71 (12), pp. 1363-1366
The pKa of diisopropylamine is around 10-11.
The pKa of bromoacetic acid is approximately 2.64.
The pKa value of Doxofylline is approximately 4.22.
The pKa of Triethylamine is approximately 10.75.
The pKa value of pyridine is 5.2.
can you take cyclizine hydrochloride when pregnant?
The pKa of diisopropylamine is around 10-11.
Cyclizine is used for motion sickness and vomiting. It is taken 30 minutes before departure and can be repeated every four to six hours as needed.
The pKa of bromoacetic acid is approximately 2.64.
Cyclizine works by blocking histamine receptors in the brain, which helps to prevent or relieve symptoms of nausea and vomiting. It also has anticholinergic properties, which contribute to its antiemetic effects.
The pKa value of Doxofylline is approximately 4.22.
The pKa of ethanol is approximately 16.
The pKa of Triethylamine is approximately 10.75.
The pKa of drotaverine is around 8.67.
The pKa value of pyridine is 5.2.
the only difference i found was that meclizine is not given to < 12 year old, only to 12 and older. cyclizine is given to age 6-12 and not <6 years old.
To calculate pKa, you can use the Henderson-Hasselbalch equation: pKa = pH + log([A−]/[HA]), where [A−] is the concentration of the conjugate base and [HA] is the concentration of the acid. Alternatively, you can look up the pKa value in a table or use a chemical database.