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  • Post-lumbar puncture headache. About 1 out of 3 people who have undergone a lumbar puncture develop a headache afterward due to a leak of fluid into nearby tissues. The headache typically starts several hours up to two days after the procedure and may be accompanied by nausea, vomiting and dizziness. Post-lumbar puncture headaches can last from a few hours to a week or more.
  • Back discomfort or pain. You may feel pain or tenderness in your lower back after the procedure. The pain might radiate down the back of your legs.
  • Bleeding. Serious bleeding can occur if you have a blood-clotting disorder or take blood-thinning or other anticoagulant medications.
  • Brainstem herniation. Increased intracranial pressure, due to a brain tumor or other space-occupying lesion, can lead to compression of the brainstem after a sample of cerebrospinal fluid is removed. A computerized tomography (CT) scan or MRI prior to a lumbar puncture can be obtained, if needed, to determine if there is evidence of increased intracranial pressure.This complication is uncommon.

MayoClinic.com

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