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micromegakaryocytes are typically seen in the peripheral blood in Myelodysplastic Syndromes (MDS) which are considered "pre-leukemia" syndromes because a high proportion of them progress to acute leukemia.

Micromegakaryocytes are caused by dysmegakaryocytopoiesis, meaning the bone marrow is not making normal megakaryocytes. Other megakaryocyte abnormalities may include large megakaryocytes that lack normal nuclear segmention, megs with two or more small unconnected nuclei, and "mononuclear" megs that lack normal nuclear lobation.

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What does peripheral blood vessels mean?

Peripheral means "at the edge". The blood vessels further away from the heart.


How does blood viscosity affect blood flow?

Peripheral resistance


Name two factors that increase peripheral resistance?

Peripheral resistance can be increased by an increase in blood volume and the constricting of blood vessels.


What is peripheral blood flow?

Peripheral blood flow refers to the circulation of blood through the blood vessels outside of the heart and lungs, supplying oxygen and nutrients to the body's tissues and organs. It is regulated by mechanisms that control blood vessel diameter and blood pressure to ensure adequate oxygen delivery to all parts of the body. Disorders affecting peripheral blood flow can lead to conditions such as peripheral artery disease or Raynaud's disease.


What is the indicator of peripheral blood flow?

Strength of pulses is one clinical indicator of peripheral blood flow. Another is capillary refill time.


How do peripheral vasodilators work?

Peripheral vasodilators work by relaxing the smooth muscle in the walls of blood vessels, which causes them to dilate and widen. This leads to a decrease in resistance to blood flow, resulting in increased blood flow to the peripheral tissues. This can help reduce high blood pressure and improve circulation.


What is the relationship between peripheral resistance and blood pressure?

Systolic BP is a measure of blood pressure while the heart is pumping; diastolic BP is a measure of blood pressure while the heart is not pumping. BP is the pressure of the blood on the walls of the blood vessels.


What decreases peripheral resistance to blood flow?

Vasodilation and decreasing blood viscosity


Would vasoconstriction decrease peripheral resistance?

No, vasoconstriction would increase peripheral resistance. When blood vessels constrict, the diameter of the blood vessels becomes smaller, which increases resistance to blood flow. This can lead to an increase in blood pressure.


What are the factors affecting peripheral resistance which influence BP?

There are three factors that increase peripheral resistance. These factors include autonomic activity, pharmacologic agents, and blood viscosity. Each factor increases the constriction of arteries, which in turn causes peripheral resistance.


What are the main factors that contribute to total peripheral resistance?

Total peripheral resistance is mainly influenced by the diameter of the blood vessels, vessel length, blood viscosity, and the compliance of the vessel walls. Vasoconstriction and vasodilation also play a significant role in regulating total peripheral resistance. Additionally, factors such as arterial blood pressure and neural and hormonal control can impact total peripheral resistance.


What would decreased peripheral resistance to blood flow?

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