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micromegakaryocytes are typically seen in the peripheral blood in Myelodysplastic Syndromes (MDS) which are considered "pre-leukemia" syndromes because a high proportion of them progress to acute leukemia.

Micromegakaryocytes are caused by dysmegakaryocytopoiesis, meaning the bone marrow is not making normal megakaryocytes. Other megakaryocyte abnormalities may include large megakaryocytes that lack normal nuclear segmention, megs with two or more small unconnected nuclei, and "mononuclear" megs that lack normal nuclear lobation.

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Q: What is the significance of micromegakaryocytes in peripheral blood?
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Where is a megakaryocyte located?

Magakaryocytes are normally found only in the bone marrow, releasing their contents (platelets) into the blood. However, in certain disorders, MDS for example, they can be found abnormally in the blood (in this case as micromegakaryocytes).


What does peripheral blood vessels mean?

Peripheral means "at the edge". The blood vessels further away from the heart.


What is peripheral blood flow?

Peripheral blood flow refers to blood flow that occurs in the extremities as opposed to blood that flows to the brain, heart, lungs, and vital organs.


Name two factors that increase peripheral resistance?

Peripheral resistance can be increased by an increase in blood volume and the constricting of blood vessels.


How does blood viscosity affect blood flow?

Peripheral resistance


What are peripheral blood stem cells?

Peripheral blood stem cells (PBSCs) are obtained from circulating blood rather than from bone marrow, but the amount of stem cells found in the peripheral blood is much smaller than the amount of stem cells found in the bone marrow.


What is the indicator of peripheral blood flow?

Strength of pulses is one clinical indicator of peripheral blood flow. Another is capillary refill time.


What is the relationship between peripheral resistance and blood pressure?

Systolic BP is a measure of blood pressure while the heart is pumping; diastolic BP is a measure of blood pressure while the heart is not pumping. BP is the pressure of the blood on the walls of the blood vessels.


What decreases peripheral resistance to blood flow?

Vasodilation and decreasing blood viscosity


What is blood flow directly proportional to?

Peripheral resistance


Decreased peripheral resistance to blood flow?

Anemia


Explain why the homeostatic mechanism of decreasing peripheral blood flow is critical to survive?

In cases of extreme trauma, such as blood loss, the body tries to preserve the internal organs by restricting peripheral blood flow.