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The biggest disadvantage is the same with any removable data storage, that it might get lost. But more than that pen drives have relatively small storage capacity. They hold out better against CD's because they are re-writable but still, in the end it actually depends on you, the purpose and if you prefer the portability of pen drives over other storage options, like an external hard drive. Or if you chose pen drives over cloud storage because you don't always have access to the internet

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