There aren't many towns on that whole stretch of I-5. Wasco is the closest to halfway.
Minturn, Colorado.
Bevis, Ohio
what is halfway point between anaheim and san diego ca
Onarga (EXIT 280 off I-57)
The halfway point between San Diego and Yosemite Valley is Bakersfield. The total amount of miles to Yosemite from San Diego is 430, requiring over 7 hours of driving.
It depends greatly on whether you take the fastest route or the shortest route. If you take the freeway to Greensboro and then north on US-29, your halfway point between Kernersville and Danville is on US-29 between Greensboro and Reidsville, near Browns Summit, NC. If you take US-158 across, then your halfway point is on US-158 on the southwest side of Reidsville
Atlantic IA, I-80 exit 60 is pretty close to the middle of the trip.
San Diego
Kansas City or Witchita.
Anadarko, OK ... just west-ish of Oklahoma City, OK
Sparta, North Carolina - just south of the Virginia line - is the halfway point.
Brush, Colorado 94 miles North-East of Denver on I76 (Route 6) is halfway between San Diego CA and Thunder Bay, Ontario.