The halfway point is Rowesville, South Carolina.
New Albany, MS, but Tupelo is close enough.
The halfway point between St. Louis, Missouri, and Fort Myers, Florida, is approximately near the area of Tallahassee, Florida. This midpoint is roughly 500 miles from both cities. Travelers may choose to stop in this region for rest or sightseeing. The exact halfway point may vary slightly depending on the chosen route.
I think it needs twelve hoers from St Louis Missouri to Daytona Beach Florida.
It is 1,004 miles according to Google Maps.
Charleston, West Virginia is halfway between Norfolk & St Louis
Panhandle, TX
Springfield
One halfway point between Saint Louis, Missouri and Manhattan, Kansas is Sweet Springs, MO.
The halfway point between St. Louis, Missouri, and Norfolk, Virginia is in or around Elementary Drive, Ona, West Virginia, 25545. Huntington lies halfway between St Louis MO and Norfolk VA
For a road trip, a town about half way between Minneapolis, MN and Destine, FL is St Louis, MO.
Rochester, Michigan is halfway between Southbend & Mississauga
Salina Kansas