If you take I-95, then Florence, SC is almost exactly half way.
The city that is the halfway point between Charlotte, North Carolina and Delaware is Dinwiddie, Virginia. This town is the exact halfway point.
Coco beach
For driving, the Delaware Memorial Bridge, near Wilmington Delaware, is close to the halfway point. It is about 73 miles from Baltimore, and 76 miles from Cape May.
Florence, South Carolina is halfway between Laurel Delaware and Orlando Florida
Charlotte NC
Columbia sx
Estesburg, Kentucky.
Rutledge, GA
The halfway point between New Philadelphia, Ohio and Millsboro, Delaware is Great Cacapon, West Virginia.
Exit 12, Rahway NY just south of Elizabeth NY on the Turnpike. Thanks to our Friends at Google maps for the info.
Halfway point between Wilmington, NC and Asheville, NC?
Hicoria, Florida is the halfway point between Largo, Florida and Boca Raton, Florida. There is approximately 251 miles between Largo and Boca Raton.