The partition coefficient of salicylic acid is approximately 2.29 at a pH of 7.4.
The partition coefficient of paracetamol is reported to be around 0.36 at pH 7.4.
partition coefficient = [s1] / [s2] [s1] is conc of drugs in phase 1 and [s2] is conc of drugs in phase 2.
6.3
Yes, the partition coefficient can influence passive diffusion rate by determining how easily a molecule can move across a membrane. A higher partition coefficient typically means the molecule is more likely to dissolve in the lipid bilayer of the membrane, thus facilitating faster passive diffusion. Conversely, a lower partition coefficient can slow down passive diffusion.
Explain partition iodine between water and vidhan tetrachloride
The partition coefficient of paracetamol in a chloroform-water system is approximately 0.22 at room temperature. This means that paracetamol tends to partition more into water than chloroform in this system.
in computational mtd,like chemoffice there r options like compute prop. where along with basic prop. partition coefficient can be calculated
pH can affect the partition coefficient by altering the ionization state of a compound. Compounds can become ionized at certain pH values, which can change their solubility in different phases. This can impact how a compound distributes between two immiscible phases.
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To determine the partition coefficient of benzoic acid between benzene and water, you would first measure the concentrations of benzoic acid in each solvent layer after equilibrium is reached. Then, calculate the partition coefficient by dividing the concentration of benzoic acid in benzene by the concentration in water at equilibrium. This ratio represents how the compound distributes between the two solvents.
The partition coefficient value provides information on how a compound distributes between two immiscible phases, typically between a water phase and an organic phase. A higher partition coefficient value suggests higher solubility of the compound in the organic phase relative to the water phase, indicating greater hydrophobicity and potential difficulty in aqueous solubility. On the other hand, a lower partition coefficient value suggests higher solubility in the aqueous phase relative to the organic phase.