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Yes, but not to fry. What do you mean by grease? Are you talking of the kind of grease used in axles? Or the kind on bicycle chains? Then no, you can't. If you mean grease as in "oil" or "fat" then yes you can. Butter, olive oil, canola oil, vegetable oil, margarine, etc will all work fine in a crock pot. But remember, unless you have the special kind of crock pots where the crock can be put on a stove top, the crock pot will not brown any meat or vegetables put into the pot. It will merely cook them slowly over a long period of time. It is best to brown meat or vegetables in a saute pan, then put them in a crock pot. That is where you would want to use the fat or oil. If you just put regular oil into a crock pot, the food will be very greasy if you put in too much. It will not evaporate away as will water or broth.

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