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The Lewis & Clark Expedition traveled up the Ohio River to the Missouri, and then up the Missouri to its headwaters on the Continental Divide. From there they traveled overland to the Snake River, down the Snake to the Columbia, and down the Columbia to the Pacific Ocean. In all, they traveled on 4 of the great rivers of North America: Ohio, Missouri, Snake, and Columbia.

The Ohio River: Begins at the confluence of the Allegheny and Monongahela rivers at the Point in Pittsburgh, PA, and flows 981 miles to join the Mississippi at Cairo, Ill. Before Lewis met up with Clark, he began the expedition on August 30, 1803 in Pittsburgh PA on the Ohio River. Lt. William Clark would offer to join Lewis on the expedition weeks later on October 13, 1803 at Camp Dubois (in present-day Indiana).

The Missouri River: Begins at the Gallatin, Madison, and Jefferson Rivers in Montana, to the Mississippi River, at St. Louis. The Lewis and Clark expedition departed St. Louis on May 14, 1804 heading up the Missouri River.

The Snake River: 1,040 miles long, chief tributary of the Columbia River. Was called Lewis' River

The Columbia River: Flows for more than 1,200 miles, from the base of the Canadian Rockies in southeastern British Columbia to the Pacific Ocean at Astoria, Oregon, and Ilwaco, Washington. On October 16, 1805, Lewis and Clark entered the waters of the Columbia. They landed at the mouth of the Columbia River, Astoria, Oregon on November 5, 1805.

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